Sequelae in 145 patients with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR). Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. © 2020 Japanese Dermatological Association. This case provides an important reminder for physicians to monitor such severe complications after DIHS.Īutoimmune sequelae drug-induced hypersensitivity syndrome human herpesvirus 6 sulfasalazine vitiligo. The occurrence of widespread vitiligo after DIHS is an extremely rare condition. Further immunoserology study showed elevated plasma C-X-C motif chemokine 10 level, which is related to vitiligo activity, in our patient. Some spontaneous repigmentation was noted 4 years after DIHS without specific treatment. Histopathological examination confirmed the diagnosis of vitiligo. Generalized hypopigmentation of the skin and leukotrichia were noted 4 months after the onset of DIHS. Reactivation of human herpesvirus 6 and possible reactivation of cytomegalovirus were detected. The patient was treated with immunosuppressants including systemic corticosteroid for approximately 1.5 years due to recurrent episodes. The patient was diagnosed with definite DIHS. We report a 47-year-old woman who presented with fever, generalized maculopapular eruption, facial edema and eosinophilia with liver function impairment after taking celecoxib and sulfasalazine for 1 month. DIHS patients have been reported to subsequently develop autoimmune disease, which may be followed by end-organ decompensation. Drug-induced hypersensitivity syndrome (DIHS) is a type of severe drug adverse reaction with high morbidity and mortality.
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